Objective: To analyze the influence of bone graft and prosthesis factors on the stress distribution in the internal structure and surrounding bone tissue of implant prosthesis. Methods: Two models of maxillary central incisor implants supported by two kinds of labial alveolar bone models were established by imaging data. The mechanical loads were carried out to analyze and describe the influence of the factors of bone graft and restoration on the stress distribution of the internal structure of the implant and the interface between the implant and bone.Results: 1. In the bone graft group, the stress values in the labial part of the retaining screw and the labial bone tissue of the implant were much lower than those in the non-bone graft group, but the stress in the neck of the implant was higher in the bone graft group than that in the non-bone graft group. 2. Under the same bone condition, the stress value of zirconia all-ceramic crown group on the lip side of retaining screw was greater than that of PFM crown group.Conclusion: Restoration factors have little effect on the stress distribution of the internal structure and surrounding bone tissue of implant prosthesis, but the difference of labial bone affected by bone graft factors can affect the stress concentration of the retaining screw and the implant-bone interface.