Objective To study the effect of different materials and porosity on the bone formation in the scaffold after the degradable bone scaffold is implanted into the human body. Methods According to the natural reaction mechanism of fracture healing, a finite element method was used, combined with the geometry of the scaffold, to establish a computationally coupled model based on the material degradation curve and the bone reconstruction control equation. Through this platform, five kinds of materials and four types of porosity representative volume elements of the scaffold were selected for calculation and analysis, and the dynamic process was reflected by the two parameters of bone density and maximum stress of the scaffold. Results The elastic modulus of the material has a greater influence on the growth of bone tissue in the stent. The smaller the elastic modulus of the material, the greater the amount of bone formation, but it will have a greater impact on the mechanical properties of the stent. The scaffold with higher porosity has lower rigidity, which can better promote the formation of bone tissue, but at the same time, it will also destroy the mechanical stability of the scaffold. Conclusions According to the performance requirements of different age, gender and location of bone tissue, it provides personalized reference and calculation basis for the selection of materials and porosity, structural design and clinical application of degradable porous bone scaffolds.