Objective To explore the spatial distribution of microstructural and mechanical properties of trabecular bone in the femoral head with osteonecrosis. Methods Microstructural and mechanical properties of trabecular bone was measured using imaging measurements and numerical simulation methods, the spatial distribution of these properties was investigated along coronal, sagittal and vertical directions. Results Microstructural and mechanical properties of trabecular bone were Y-shaped distributed along coronal and sagittal directions, which is consistent with the location of the principle compressive group in the femoral head. Mechanical properties of trabecular bone in the Y-shape were higher than the other areas. Conclusions Necrotic lesions in the Y-shape could bring more change to the stress distribution and cause the deterioration of osteonecrosis.