Tympanic membrane perforation is one of common diseases in otolaryngology.The main causes of tympanic membrane perforation are otitis，trauma and etc. With the rapid development of finite element analysis methods,scholars try to apply this method to the clinical evaluation of tympanic membrane perforation and repair materials. In the study,we analysis the characteristics of tympanic membrane perforation and tympanic membrane repair materials from Biomechanical angle through the establishment of a finite element model of the middle ear,and combine with clinical application results. This article focus on the research progress of the tympanic menbrane perforation and tympanic membrane repair materials.