从基质黏弹性和钙信号深入理解骨性关节炎发病机制
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Deeper Understanding the Pathogenesis of Osteoarthritis from Matrix Viscoelasticity and Calcium Signaling
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    摘要:

    细胞外基质普遍具有黏弹性特征。在骨性关节炎(osteoarthritis,OA)中,分解代谢过程改变软骨细胞功能性周基质的黏弹性特性。软骨细胞通过一系列力敏感受体和离子通道感受和响应基质力学微环境的变化,与此同时激活复杂的下游信号通路并调控与OA病理密切相关的细胞过程。深入理解关节软骨细胞感受基质微力学环境的力转导机制将有助于软骨组织工程基质微环境构建和OA精准靶向治疗。本文简要评述Agarwal等人关于基质黏弹性调控软骨细胞的力转导机制,并拓展讨论与之相关的最新研究进展。

    Abstract:

    Generally, extracellular matrix (ECM) has the characteristics of viscoelasticity. In osteoarthritis (OA), catabolic processes alter the viscoelastic properties of functional pericellular matrix (PCM) of chondrocytes. Chondrocytes sense and respond to their mechanical microenvironment via an array of mechanosensitive receptors and channels that activate a complex network of downstream signaling pathways to regulate several cell processes central to OA pathology. Advances in understanding the specific mechanosignalling mechanisms in articular cartilage will promote the development of cell microenvironment construction in cartilage tissue engineering and the targeted precision therapeutics for OA. In this review, the work on the mechanism of matrix viscoelasticity regulating chondrocytes mechanotransduction by Agarwal et al. was briefly commented, and the recent advances related with their work was also discussed.

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张全有,陈维毅.从基质黏弹性和钙信号深入理解骨性关节炎发病机制[J].医用生物力学,2022,37(1):1-3

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  • 收稿日期:2022-02-11
  • 最后修改日期:2022-02-14
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  • 在线发布日期: 2022-02-25
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