巨噬细胞力学信号转导通路的研究进展
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浙江大学医学院附属第一医院

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Advances in mechanotransduction pathway of macrophage
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    摘要:

    微环境中的机械力学刺激,如基质刚度,表面形貌,循环牵张等,通过细胞膜上受体为巨噬细胞所感知,可沿着粘附蛋白分子链和细胞骨架向细胞核内传递,并转导为生化信号激活基因转录,进而驱动粘附、增殖、迁移、极化等生物学行为,在疾病进展和组织再生中发挥相应作用。本研究旨在论述微环境中机械力学刺激对巨噬细胞表型和功能的影响,阐明巨噬细胞机械转导通路的相关机制,为靶向巨噬细胞的免疫调节型生物材料研发,提供分子生物力学的新思路。

    Abstract:

    Microenvironment mechanics, such as matrix stiffness, surface topography, cyclical stretch, etc., can be perceived by macrophages through receptors on the cell membrane, transmitted to the nucleus along the adhesion protein molecular chain and cytoskeleton, and also converted into biochemical signal to stimulate gene transcription. Furthermore, macrophages differentiate into specific phenotypes in response to various microenvironment mechanics and exhibit specific biological functions, such as adhesion, proliferation and migration, thus playing a significant role in disease progression and tissue regeneration. This study aims to elucidate the role and mechanism of microenvironment mechanics in macrophage polarization, and provides molecular biomechanics insights into the development of macrophage-targeting immunomodulatory biomaterials.

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  • 收稿日期:2022-04-20
  • 最后修改日期:2022-06-08
  • 录用日期:2022-06-09
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