目的 探讨利用GS-MEP方法对大鼠脑干锥体束损伤后产生的运动功能障碍进行定量研究。方法 雄性（Sprague-Dawley,SD）大鼠30只，分为1.25ｍ致伤组、2.25ｍ致伤组和正常组，采用经典Marmarou模型制作锥体束部位的创伤性轴索损伤模型，致伤组均于损伤后1d、3d、5d、7d、14d、28d、42d对大鼠进行肢体抓力GS信号和MEP运动诱发电位波幅的检测，三组大鼠均于麻醉后相应时间进行对照检测。结果 致伤组随损伤程度的增加，MEP波幅和GS最大抓力下降比例明显增大；两个高度GS与MEP的测量值具有明显正相关性。损伤程度较小时，前期MEP比较敏感，后期MEP不敏感；损伤程度较大时，前期与后期MEP变化均较为敏感。结论 采用GS-MEP联合评估可以为锥体束损伤后产生的运动功能障碍程度的定量评价提供数据支持。
Objective To quantitatively investigate the motor dysfunction after brain stem pyramidal tract injury in rats by GS-MEP. Methods Thirty healthy male SD rats were randomly divided into 1.25m injury group, 2.25m injury group and normal group. The classical marmarou model was used to make the traumatic axonal injury model of pyramidal tract. In the injury group, the GS signal of limb grasping force and MEP motor evoked potential were detected before injury and 1d, 3d, 5d, 7d, 14d, 28d and 42d days after injury，and the control test was carried out at the corresponding time after anesthesia. Results There was no significant change in the indicators of the normal group. With the increase of the injury degree, the MEP amplitude and GS maximum grip decreased significantly in the injured group; The measured values of the two heights GS and MEP have obvious positive correlation. In the case of less damage, MEP is more sensitive in the early stage, but not in the late stage; In the case of large degree of damage, MEP changes in the early and late stages are more sensitive. Conclusion The combined evaluation of GS-MEP can provide an objective basis for the quantitative evaluation of motor dysfunction after pyramidal tract injury.