基于动态共价键的粘弹性可调复合水凝胶生物医学研究进展
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太原理工大学生物医学工程学院

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R 318. 01

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Progress in the biomedical of viscoelastic tunable composite hydrogel based on dynamic covalent bonds
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College of Biomedical Engineering,Taiyuan University of Technology

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    摘要:

    水凝胶具有良好的生物相容性以及与天然生物组织相似的力学性能,已广泛应用于生物医学领域。随着生物力学的发展,越来越多的研究者发现,基于动态共价键构筑的粘弹性可调复合水凝胶,其优越的生物力学特性和刺激响应性,能更好地模拟生物组织和天然细胞外基质(extracellular matrix,ECM)随时间变化的粘弹性力学特性。本文详细总结了基于不同类型的动态共价键(亚胺键、二硫键、硼酸酯键等)所构筑的粘弹性可调复合水凝胶的在调控细胞功能、影响组织再生修复以及药物递送等领域的应用,并提出了未来研究所面临的挑战与机遇。

    Abstract:

    Hydrogels possess good biocompatibility and mechanical properties similar to those of natural biological tissuessimilar mechanical properties to natural biological tissues,and have been widely used in biomedical fields. With the development of biomechanics,more and more researchers have found that the viscoelastic tunable composite hydrogels constructed based on dynamic covalent bonds ,with its superior biomechanical properties and stimulus responsiveness,can better simulate the viscoelastic mechanical properties of biological tissues and natural extracellular matrix (extracellular matrix, ECM) over time due to their superior biomechanical properties and stimulus responsiveness. This paper summarizes in detail the applications of viscoelastic tunable composite hydrogels constructed based on different types of dynamic covalent bonds (such as imide bonds,disulfide bonds,borate ester bonds,etc.) in the fields of regulating cell function,affecting tissue regeneration and repair,as well asand drug delivery,and presents the challenges and opportunities for future research.

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  • 收稿日期:2024-03-12
  • 最后修改日期:2024-05-04
  • 录用日期:2024-05-06
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