基于全节段实验与有限元反演的猪主动脉超弹性参数库构建
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清华大学第一附属医院

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北京华信医院领航(2024-LH-02),首都临床特色诊疗技术研究及转化应用(Z221100007422021)


Development of a Hyperelastic Parameter Library for the Porcine Aorta Based on Full-Segment Experiments and Finite Element Inverse Analysis
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The First Hospital of Tsinghua University,Department of Vascular Surgery

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    【目的】针对当前猪主动脉力学数据缺乏系统性、本构模型筛选缺乏系统依据,且材料参数缺乏有效的实验验证,本研究旨在通过系统的实验与仿真,构建一套高置信度的猪胸腹主动脉超弹性力学参数库。【方法】获取10头健康家猪的完整主动脉,系统划分为7个解剖节段,分别沿周向和轴向制备试样进行单轴拉伸实验,获取应力-应变曲线,基于实验数据,对比五种超弹性本构模型的拟合效能,优选最优模型并利用网格搜索算法进行批量参数拟合,后续通过有限元仿真反演单轴拉伸过程,验证参数的准确性。【结果】共获得751例有效数据,结果表明猪主动脉力学性能从近心端到远心端呈现极限拉伸强度递增而极限伸长率递减的梯度变化,同时表现出强烈的各向异性;通过综合评估,三参数Yeoh模型被确定为最优本构模型(R2 > 0.99),有限元反演验证显示,仿真曲线与实验曲线高度吻合,从而建立了涵盖各节段与方向的Yeoh模型参数库。【结论】本研究系统量化了猪胸腹主动脉力学特性的节段差异性与各向异性,成功筛选出Yeoh模型并建立了经过验证的、可靠的超弹性参数库,为后续主动脉疾病的生物力学研究及相关医疗器械的有限元仿真提供了精准的数据基础。

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    Objective In response to the current challenges of unsystematic mechanical data for the porcine aorta, a lack of systematic criteria for constitutive model selection, and insufficient experimental validation of material parameters, this study aims to construct a high-fidelity hyperelastic mechanical parameter library for the porcine thoracoabdominal aorta through an integrated experimental and computational approach. Methods The complete aortas were harvested from 10 healthy adult domestic pigs. Each aorta was systematically dissected and divided into seven anatomical segments. Dumbbell-shaped specimens were prepared along the circumferential and axial directions from each segment. Uniaxial tensile testing to failure was performed to obtain stress-strain curves. Based on the experimental data, the fitting efficacy of five hyperelastic constitutive models was compared to select the optimal model. The grid search algorithm was employed for batch parameter fitting of the optimal model. Subsequently, the uniaxial tensile process was numerically simulated via finite element analysis to inversely

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  • 收稿日期:2026-01-30
  • 最后修改日期:2026-03-02
  • 录用日期:2026-03-03
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