Objective To measure and compare maximum resist compressive strength and torsional strength of newly-designed expansion cancellous screw with that of cannulated compression screw in fixation of femoral neck fracture, and to evaluate the effects of ECS screws. Methods Eighteen pairs (thirty six specimens) of cadaveric human proximal femurs were randomly divided into three groups, i.e. each group with six pairs (twelve specimens). Simulate uniped standing and compare the maximum femoral neck strength and torsional strength with using screws in different types and numbers, i.e. two ECS and two CCS, two ECS and three CCS, three ECS and three CCS. Result The maximum femoral neck strength and torsional strength from fixation with ECS was significantly greater than that of CCS with the same types and numbers; the fixations with two ECS and with three CCS showed no significant difference. Conclusions The results suggested that as compared with CCS, the expansion cancellous screws might have better effect in femoral neck fracture. The fixation effect with two ECS sometimes could have the same virtue as that with three CCS.