Study on the degree of functional injury of brainstem pyramidal tract in SD rats based on GS-MEP
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    Abstract:

    Objective To quantitatively investigate the motor dysfunction after brain stem pyramidal tract injury in rats by GS-MEP. Methods Thirty healthy male SD rats were randomly divided into 1.25m injury group, 2.25m injury group and normal group. The classical marmarou model was used to make the traumatic axonal injury model of pyramidal tract. In the injury group, the GS signal of limb grasping force and MEP motor evoked potential were detected before injury and 1d, 3d, 5d, 7d, 14d, 28d and 42d days after injury,and the control test was carried out at the corresponding time after anesthesia. Results There was no significant change in the indicators of the normal group. With the increase of the injury degree, the MEP amplitude and GS maximum grip decreased significantly in the injured group; The measured values of the two heights GS and MEP have obvious positive correlation. In the case of less damage, MEP is more sensitive in the early stage, but not in the late stage; In the case of large degree of damage, MEP changes in the early and late stages are more sensitive. Conclusion The combined evaluation of GS-MEP can provide an objective basis for the quantitative evaluation of motor dysfunction after pyramidal tract injury.

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History
  • Received:October 26,2022
  • Revised:December 03,2022
  • Adopted:December 08,2022
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