Analysis on Motion Characteristics of Red Blood Cells in Capillaries
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    Abstract:

    Objective To study the motion and deformation of red blood cells ( RBCs) with different mechanical properties in capillaries,and make analysis on the associated hemorheological parameters. Methods The RBC was modeled as a hyper elastic membrane using Skalak model. The fluid was solved using a two-order difference scheme with the membrane mechanics treated by the immersed method. The pathological viscosity ratio λ= 5 was considered. Results The steady deformation of RBCs with different membrane stiffness in the capillary was obtained. With membrane stiffness increasing, the cell transformed from axisymmetric shapes to non-axisymmetric shapes. With capillary number increasing, the deformability of RBCs weakened and the flow resistance increased. Conclusions With stiffening of cell membrane, the non-axisymmetric cell shape appears and the flow resistance increases. Therefore, in diseases involved stiffening RBCs, the stiffened RBCs can cause the blockage of capillaries and hypoxia in surrounding tissues.

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LIU Deyun, GONG Xiaobo. Analysis on Motion Characteristics of Red Blood Cells in Capillaries[J]. Journal of medical biomechanics,2023,38(1):123-128

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History
  • Received:March 02,2022
  • Revised:April 17,2022
  • Adopted:
  • Online: February 28,2023
  • Published: