[Objective] To analyze the adaptability of different materials based on a defined coronary stent design and to establish an evaluation method for stent design-material selection. [Methods] Using finite element numerical simulation methods (FEA), the expansion performance of the stent in the blood vessel were analyzed, and the safety and usability of the stent design and materials were investigated for five potential applicable materials. For the permanent materials, the focus was on the fatigue resistance performance after long-term implantation; while for the degradable materials, the changes of support force during degradation were analyzed to clarify the rules of the support force provided by the stent. [Results] For the specific coronary stent design, the results given by the FEA showed that for 316L stainless steel and L605 cobalt-chromium alloy stents, the radial resilience were 25% and 19%, the axial shortening were 0.22% and 0.28%, the maximum equivalent forces were 551.2 MPa and 829.1 MPa, and the fatigue dynamic safety factors were 1.33 and 1.67, respectively. The simulated damage times of the stents based on this design were 30 hours, 6 months and 9 months for the degradable materials such as AZ31 magnesium alloy, iron and poly(L-lactic acid) (PLLA), respectively. [Conclusion] Based on the stent design in this paper, the L605 cobalt-chromium alloy exhibited the best expansion performance and fatigue resistance to match the clinical requirements. Compared with the rapid degradation damage of AZ31, the mechanical properties of iron stent and PLLA stent are close but still need structural optimization. While FEA, especially the expansion performance analysis and fatigue resistance analysis, can be effectively used to simulate the mechanical behavior of the stent and provide basis for the selections of stent materials and the design optimizations.