Objective To establish a mathematical model of carotid baroreceptors based on matlab / Simulink plateform. Methods This mathematic model was composed of three parts, including carotid sinus baroreceptor afferent path, sympatric nerve together with vagus nerve efferent path, and reflex effector. The model was validated using animal experimental results. Results It was found that the results of the model analysis were similar to that obtained from rat carotid reflex experiment. Conclusion The structure of the model was clear and extendable, suggesting that the model could be used as an alternative method for animal experiments.