Objective To investigate the effect of simvastain on the biomechanical characteristics of femur in ovariectomized rats.Methods 48 female SD Rats were randomized divided into three groups:Sham-operated group (S),ovariectomized group(OVX)and Simvastatin ovariectomized rats group(OVX+SIM).8 weeks later,Simvastatin were administered orallywith 5mg·kg-1·d-1 to OVX+SIM group and normal saline to the other two groups.The rats were killed separately 4 weeks and 12 weeks after operation.The femora were taken out for the three-point bending test to measure the maximal loading,flexibility loading,flexibility strain,maximal strain,coefficient of bending stiffness,coefficient of bending ductility of the femur.Results(1)The maximal loading and the maximal strain of femur in SHAM group was significantly higher than that in the OVX group(P<0.05)at 4 weeks after treatment.The coefficient of bending ductility of the femur in the OVX+SIM group was significantly higher than that in the OVX group(P<0.01)while the the flexibility loading of the femur in OVX+SIM group was significantly lower than that in the OVX group(P<0.05)at 4 weeks after treatment.(2)12 weeks after treatment,the maximal loading of the femur in the OVX+SIM group or that in the SHAM group was significantly higher than that in the OVX group(P<0.05,P<0.01),the flexibility loading of the femur in the OVX+SIM group was significantly higher than that in the OVX group(P<0.05),the coefficient of bending ductility of the femur in the OVX+SIM group or that in the SHAM group was significantly lower than that in the OVX group(P<0.05,P<0.01);(3)The maximal loading of the OVX+SIM group,the flexibility loading of the OVX+SIM group￡﹁or the coefficient of bending ductility of the OVX group at 12 weeks after treatment was significant higher than that at 4 weeks after treatment with statistically significant(P<0.01).Conclusion Simvastain could affect the bone remodeling and improve the biomechanical properties characteristics of the femur of the ovariectomized rats.