Objective To evaluate the effect by partial solidification of track on strengthening pedicle screw fixation in vitro. Methods 30 fresh adult goat lumbar vertebrae were harvested. Usual fixation of pedicle screw was given to one side of each lumbar vertebrae (blank group),and partial solidification of track before fixation of pedicle screw was given to the other side (experiment group). 10 lumbar vertebrae were selected randomly followed by axial pullout test and periodical bending resistance test was performed on the other 20 lumbar vertebrae in 24 hours after the fixation.R esults: The maximum axial pullout strength is (637.60±109.95) N in blank group and (816.50±134.88) N in experiment group; energy absorption value is (1.268±0.252) J in blank group and (1.631±0.269) J in experiment group. There is significant difference between two groups (P<0.05). The screws in experiment group can resist more loading or reduce fewer shifts under the same loadings compared with screws in blank group in periodical bending resistance test. Conclusions: Partial solidification of track can significantly strengthen the stability of pedicle screw fixation and provide a novel clinical method to solve loosing of screws. It has a favorable perspective in clinical application.